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2000), several studies have demonstrated good concordance of the assay with the in vivo transgenic rodent (TGR) somatic mutation assay and also high sensitivity of 92.1% (35 out of 38 chemicals correctly identified) for detecting human IARC group 1 and Group 2A carcinogens, comparable to the TGR assay with 90.3% (Kirkland et al
Common criteria include failed trials of oral diabetes medications, documented BMI thresholds (often 30+), and baseline metabolic or cardiometabolic risk factors
[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Balunas M.J., Kinghorn A.D
