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Currently there is no established upper limit for B12 due to the low potential for toxicity

Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
Clearing 4-HNE or enhancing its detoxification capacity through acetaldehyde dehydrogenase and GSH pathways has shown neuroprotective effects in PD models (88)

Notably, post-mortem studies revealed reduced activity of respiratory chain complexes in a group of ASD children, suggesting that abnormalities, especially in the frontal, temporal and cerebellar areas (Chauhan et al., 2011