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Malondialdehyde (MDA) concentration was spectrophotometrically quantified via thiobarbituritic acid (TBA) reaction

Similarly several months exposure to ozone or to a prolonged oxidative stress due to a chronic inflammatory disease (atherosclerosis, diabetes, cancer) can possibly raise 4-HNE plasma levels up to 5-20 M and, in spite of continuous detoxification, they can exert pathological effects as those observed in vitro studies performed with leukemic cells [39], lens epithelial cells [40], Jurkat T cells [41] and when testing cholesterol secoaldehyde (CSeco) in cardiomyoblasts [31]

Nov 2016;215(5):579.e1-579.e5

Treatment of muscle cramps in patients with cirrhosis of liver: a systematic review