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Statements Author contributions CP and TZ designed and conceptualized this paper

Subcutaneous injection delivers consistent plasma concentrations regardless of digestive state, though fasted administration still improves uptake by 2530% due to reduced amino acid competition

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Sustained UPR can promote the development of MAFLD by regulating lipogenesis, causing inflammation, and inducing hepatocyte death (Lebeaupin et al., 2018
