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In ob/ob mice and Zucker rat models, it has consistently reduced fat mass, decreased epididymal and brown adipose tissue weight, and improved lipid profiles without affecting lean tissue or glucose homeostasis

6 Reduced levels of B12 and folate compromise the bodys ability to convert homocysteine to methionine, leading to elevated homocysteine

The bone volume/tissue volume (BV/TV) of the upper and lower end plates of each intervertebral disc were measured

Post hoc assessments included change in SBP and DBP from week 0 to week 68 for cagrilintide and semaglutide groups versus placebo and by baseline hypertension (yes/no) in each treatment group