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The most important determinant of this compartmentalization is the polyglutamate tail

While the genes upregulated more by decursinol angelate primarily encode growth factors, the genes upregulated more by decursin primarily encode extracellular matrix (ECM) remodelling proteins and inflammatory cytokines

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For example, a custom-designed nanocarrier for IL-10 DNA delivery was developed by screening a library of cationic polymers using high-throughput testing in macrophages ( 2.2.2 mRNA delivery RNA-based medicine has emerged as an alternative to DNA-based medicine due to technological breakthroughs such as the Nobel Prize winning development of nucleoside base modifications ( Given the inherent risk of systemic IL-12 administration, it is important that exogenous use of this cytokine be restricted to the local TME