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SARS-CoV-2 mainly destroys pulmonary surfactant-secreting type II alveolar cells (Wang et al., 2021a), that normally decrease the air/tissue surface tension and block TLR4 in the lungs, promoting ARDS and inflammation

Despite extensive research, the precise molecular mechanisms driving the initiation and progression of PD remain incompletely understood

In: Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application
