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Two other studies demonstrated that the silica exposure-induced overproduction of ROS is associated with the degradation of the NF-B inhibitor IB- and activation of the NF-B pathway because a pretreatment with NAC decreased a silica-induced accumulation of ROS and inhibited the suppression of IB- [179], or reduced the activation of NF-B [187]
Beers MH, Jones TV, Berkwits M, et al, eds

10.3899/jrheum.090069 360
