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Description
In these models, we take into account the reaction geometry of common thiol-disulfide exchange reactions and distinguish hypothetical protein areas that might either interact with the disulfide substrate (a scaffold site) or the reducing agent (an activator site) (Fig
29, S235S236
KEAP: Kelch-like ECH-associated protein
Nrf2 regulates key components of anti-ferroptotic pathways, positioning it as a central modulator of lipid peroxidation and ferroptosis (62)
