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Combinatorial GeneGeneEnvironment CRISPR screen targeting human SLC25 transporter family enables the identification of SLC25A39 in mitochondrial glutathione import and its coordination with mitochondrial iron import in supporting OXPHOS.

Mechanistically, stabilization of wild-type p53 and induction of the p53 target gene CDKN1A (p21) leads to decreased expression of the ribonucleotide reductase (RNR) subunits RRM1 and RRM2

L-glutathione is a key factor in supporting immune system health, cellular energy production, balancing oxidative stress, and detoxing tissues of environmental toxins and cellular waste products

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