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Cobalamin bound to transcobalamin (forming holotranscobalamin) represents the circulating bioavailable form of vitamin B12, which is subsequently absorbed by peripheral cells via endocytosis mediated by the receptor CD320 (also known as the transcobalamin II receptor), a ubiquitous cell surface receptor of the LDLR family (10)

However, several like Semaglutide and Tirzepatide for weight loss and diabetes have FDA-approved applications and are widely used under physician supervision