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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

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A rare cause is transcobalamin II deficiency, a genetic condition where your body can't transport B12 (also known as cobalamin) in your body

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LA-12: A methylcobalamin formulation commonly used for energy support

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Hoping that it improves over next few weeks

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