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Beyond peptides, targeting molecules like aptamers (short DNA or RNA strands that bind specifically to targets), small molecules (designed to interact with disease-related receptors or enzymes), and carbohydrates (for targeting specific cell surface lectins or receptors) are also under investigation for their therapeutic potential [56,57,58,59,60]

An increased MMPs/tissue inhibitor MMPs (TIMPs) ratio is more strongly associated with tissue response to LPS-linked injury than with the acute-phase reaction (242, 243)

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