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HINOURA2, and B.K

[DOI] [PubMed] [Google Scholar] Luo J, Mills K, le Cessie S, Noordam R, van Heemst D

149 published a randomized control trial using hypothermia or hypothermia plus melatonin in 80 babies with HIE where melatonin improved survival rate

These reactions resolve on their own and typically diminish with continued use as technique improves
