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SERT HVA: 4-Hydroxy-3-methoxyphenylacetic acid, Homovanillic acid i.p.: Intraperitoneal ICV: Intracerebroventricular i.v.: Intravenous K e : Elimination constant KO: Knockout LSD: Lysergic acid diethylamide MAO: Monoamine oxidase MAOi: Monoamine oxidase inhibitor MDA: ()-3,4-Methylenedioxyamphetamine MDEA: Methylenedioxyethylamphetamine MDMA: ()-3,4-Methylenedioxymethamphetamine, Ecstasy -MeDA: -Methyldopamine, 3,4-Dihydroxyamphetamine, HHA METH: Methamphetamine 4-MTA: 4-Methylthioampethamine mtDNA: Mitochondrial DNA MPT: Mitochondrial permeability transition NA: Noradrenaline NAC: N-Acetylcysteine NAT: Noradrenaline transporter NMDA: N -methyl-d-aspartic acid N-Me--MeDA: N -methyl--methyldopamine, 3,4-Dihydroxymethamphetamine, HHMA NO : Nitric oxide radical O 2 : Superoxide anion ONOO : Peroxynitrite PET: Positron emission tomography PD: Pharmacodynamic PK: Pharmacokinetic PKC: Protein kinase C p.o.: Per os PMA: p -Methoxyamphetamine RNS: Reactive nitrogen species ROS: Reactive oxygen species s.c.: Subcutaneous -SH: Sulfhydryl SPECT: Single-photon emission computed tomography SOD: Superoxide dismutase SULT: Sulfotransferase t 1/2 : Elimination half-life TH: Tyrosine hydroxylase THC: 9 -Tetrahydrocannabinol T max : Median time to maximum concentration TPH: Tryptophan hydroxylase UGT: UDP-glucuronosyltransferase UK: United Kingdom USA: United States of America VMAT: Vesicular monoamine transporter WT: Wild type References Abourashed EA, El-Alfy AT, Khan IA, Walker L (2003) Ephedra in perspective-a current review
In diazepam chronically treated mice, it attenuated diazepam tolerance (provoked by later acute administration of diazepam together with convulsant) and postponed physical dependence/withdrawal effects (provoked by later administration of isoniazid)

Maintaining this diversity underpins immune homeostasis and resilience against infections

28, 30 Caution is advised when prescribing colchicine to patients who are taking medicines that inhibit the CYP3A4 enzyme and/or P-glycoprotein, e.g