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Box A: Diversity of GPCR ligands Neurotransmitters norepinephrine adenosine histamine serotonin dopamine cannabinoids opiates acetylcholine GABA glutamate Peptide hormones endothelin glucagon angiotensin II GSH, FSH, CRH GnRH, ACTH Tastants, oderants, light Learning Objectives 1

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While PLC1 is ubiquitously expressed in multiple tissues, PLC2 is mainly expressed in hematopoietic cell lineages 34

Another confounding feature, especially in transcriptomic analysis of tumors, is that IDO1 expression is increased in M1 macrophages [156], probably as a means to fine-tune the tissue-destructive effect of these cells