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This article explores key ligands that can enhance blood-brain barrier crossing of agar-based nanoparticles, including transferrin, lactoferrin, Angiopep-2, and glutathione, along with design strategies for improved brain delivery.

Background Parkinson's disease is a neurodegenerative disorder characterized pathologically by the loss of nigrostriatal dopamine neurons that project from the substantia nigra in the midbrain to the putamen and caudate nuclei, leading to the clinical features of bradykinesia, rigidity, and rest tremor
