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Introduction Hyperammonaemic encephalopathy (HE) is a condition characterized by dysfunction of the central nervous system due to excessively high levels of ammonia (NH 3 ) in the blood (hyperammonaemia) ( The association between VPA, a widely used AED, and HE has been has been extensively documented in numerous studies, indicating a significant correlation between the two

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In general, metabolic dysregulation accelerates aging, whereas metabolic interventions have been shown to extend lifespan [118].This relationship underscores the complex link between aging and metabolism

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The primary cause of biofilm persistence in chronic infections is a combination of enhanced beta-lactamase expression and other protective features of the biofilm growth mode [35]

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