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1a), treatment with Ht-PreHNE(alkyne), washout of excess unbound probe and light exposure liberates HNE(alkyne) ( t 1/2 photouncaging 90% silencing efficiency in both KO lines

Several factors can enhance neuroplasticity, including enriched environments, physical exercise, and pharmacological treatments such as selective serotonin reuptake inhibitors (SSRIs), N-methyl-D-aspartate (NMDA) receptor modulators like ketamine, and neurotrophic agents such as BDNF enhancers

Additional examinations utilizing ESR assessed the relative potential of GHK in neutralizing OH radicals compared to other antioxidants like carnosine and reduced glutathione (GSH), both recognized for their antioxidant capabilities

on the other hand, excess copper induces high levels of ROS through the Fenton reaction, leading to severe oxidative damage in proteins, lipids, and DNA (Guo et al., 2025)