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Thus, IRE1 activity with two distinct outcomes indicates IRE1s important role in determining cell fate during ER stress

doi: 10.1016/j.bbadis.2009.08.013

This notion also extends to in vitro studies, whether in human or animal cell lines, that often report the use of sulforaphane concentrations in far excess of what is likely achievable in human tissues as peak levels, never mind the short biological half-life in vivo that quickly attenuates the duration of the exposure

Mutation L1014F, which upon homozygosity has been associated with operationally significant resistant phenotypes and striking ones, when in combination with P450 metabolic resistance 21 has been recorded in Cx