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Reversal capacity does decrease in the end stages or with cirrhosis complications

10.1016/j.cell.2017.09.021 Redox Biol

A potential complication of zinc deficiency treatment is overcorrection with zinc supplementation since this can cause acute zinc toxicity [1] Other clinical conditions that may show low zinc levels are tabulated in Table 4

While some studies suggest SIRT6 acts as a tumour promoter by preventing DNA damage and cellular senescence [205], others indicate that it suppresses tumour growth by inhibiting the ERK1/2 pathway [206]
