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It is a heterogeneous group, as different can be the causes of the better adaptation of a cell to hypoxia, but the common factor is that cells more equipped to survive in hypoxia, are more likely to remain vital and able to growth after treatment-induced reduction of the vascularity

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From what is known of the enzyme kinetics of the glutathione conjugation of model xenobiotic substrates, the reactions would be anticipated to undergo a random sequential two-substrate, two-product mechanism with the overall reaction rate being determined by the rate of release of reaction product from the active site [37]