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Description
It was being developed at the time
Independent of its trafficking function, S1P signaling was elegantly shown to be necessary for maintaining naive T cell mitochondrial content and function in vivo (46)
A molecule that binds IGFBPs poorly gains free-ligand availability at any given moment but forfeits the reservoir that would otherwise keep it in circulation so more active per molecule and present in the body longer are not the same property, and the second does not automatically follow from the first
[DOI] [PubMed] [Google Scholar] 92.Slivka A., Spina M.B., Cohen G
