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Below, we summarize and discuss the latest advances in three major categories of potential therapeutic strategies, including specific inhibitors of inflammatory pathways, stem cell-based immunomodulatory therapy, and epigenetic regulation interventions, with a focus on their mechanisms of action, preclinical efficacy, and translational potential in the management of varicocele-related disorders

The mitochondrial release of apoptosis-inducing factor (AIF) and of endonuclease G (EndoG), which is extremely specific for myonuclei, occur, which are responsible for DNA fragmentation and chromatin condensation, as well as the collapse of the nuclear envelope ( Fig

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TABLE 1 Demographics of participants