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Wiktelius E, Stenberg G

Drugs administered by IN penetrate through the nasal epithelial barrier, followed by diffusion into the perivascular or perineural spaces, and finally throughout the brain though some of the drug will be lost by entering the lymphatic and systemic blood circulation [12]

Kozaniti et al., 2021

In the equatorial Pacific cold tongue, the DSST contribution is negative and of comparable magnitude (~ 4%), except in February, March, and April, when the contribution becomes positive
