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It is also involved in the regulation of the expression of numerous genes, the protection of various biomacromolecules from oxidative damage, the stimulation of energy production (ATP) [124,125], and other effects

Animal models show that spontaneous hypertension can be due to reduced GABA inhibition in the part of the hypothalamus that regulates blood pressure
[DOI] [PubMed] [Google Scholar] 54.Sigmon D, Kumar S, Carpenter B, et al
Hence, choose drugs with a lower pKa