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The immune reaction to disease depends on fast replication of cells, which itself depends on adequate availability of B12 and folate

Refrigeration at 4 C (39 F) extends shelf stability and is recommended for long-term storage

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The NIH Office of Dietary Supplements, citing Institute of Medicine recommendations, advises that it is advisable for those older than 50 years to meet their RDA mainly by consuming foods fortified with vitamin B12 or a supplement containing vitamin B12. This recommendation reflects the fact that 10 to 30% of older adults lose the ability to efficiently absorb naturally occurring B12 from food