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It counteracts calcium, which triggers muscle contraction, thereby preventing the painful spasms and involuntary twitching frequently seen in dysautonomia and ME/CFS

This dysfunction includes structural and functional changes in the presynaptic terminal, synaptic cleft, and postsynaptic dendrites

Retatrutide activates the glucagon receptor, which tirzepatide does not

10.3389/fimmu.2020.00353 218 SongJ.ZhangY.FrielerR