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doi:10.15252/embj.2018101230

As he points out, this altered glutathione/oxidized glutathione ratio in the substantia nigra suggests that oxidative stress may be a component in the pathogenesis of nigral cell death in PD
doi: 10.1093/ajcn/87.3.753
Consequently, dihydrolipoyl transacetylase cannot accept the hydroxyethyl group from TPP because it is maintained in the acetylated form