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Description
Lin28B derived from BC exosomes stimulates lung fibroblasts, neutrophils, and macrophages to release CXCLs, IL-6, and IL-10, respectively, resulting in neutrophil recruitment and N2 transformation, creating an immunosuppressive microenvironment conducive to tumor metastasis [131]
It should be initiated before or at the start of therapy and reinforced periodically throughout the treatment course
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doi: 10.1136/bmjopen-2019-033687
