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Studying the glutathione redox imbalance and mitochondrial abnormalities in embryonic AS NPCs provides an essential insight into the involvement of UBE3A in early neural development, information that can serve as a powerful avenue towards a broader view of AS pathogenesis

This is an evolving area of extensive research and controversy with variable results in the animal and epidemiologic literature

It plays a central role in cellular redox homeostasis, xenobiotic detoxification, and immune regulation, and is one of the most widely studied compounds in biochemistry and oxidative stress research

THE REFINED STRUCTURE OF THE SELENOENZYME GLUTATHIONE PEROXIDASE AT 0.2-NM RESOLUTION