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BDNF regulates synaptic plasticity through interactions with the tropomyosin-related kinase B (TrkB) receptor and induction of several signaling cascades that are involved in the regulation of synaptic plasticity and cAMP-responsive element-binding protein (CREB)-dependent gene expression 13

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These facts paved the way for the development of a GIP receptor agonist-based therapy for T2DM, looking also for the possibility of finding a dual GLP-1/GIP receptor agonist [17]

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