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Low serotonin levels are associated with depression and insomnia, and when serotonin levels are normalized, sleep improves

The composition of the ECM is different in Acomys wounds and molecules like collagen triple helix repeat containing-1 (CTHRC-1), tenascin-C, fibronectin 1, laminin 1, and aggrecan are upregulated and correlated to a regeneration-inducing environment, although no mechanistic details have been attributed to these components individually 63

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Consider reducing to the previous tolerated dose for an additional 4 to 8 weeks before attempting re-escalation