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Description
This isn't just aging
This disruption initiates a critical sequence of events: it promotes the phosphorylation of p53 and facilitates its translocation to the cytoplasm
Its known that 22 splice variants of hTERT exist (Plyasova and Zhdanov 2021) however, only the full-length variant codes for the fully active telomerase enzyme and some variants can act in a dominant negative way to inhibit telomerase activity
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