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The quantification of the difference in isoform usage is accomplished by calculating the difference in isoform fraction (dIF), which is computed as the IF in condition B - IF in condition A

This process yields an excess of reactive oxygen species (ROS), which impairs endothelial function, reduces the bioavailability of nitric oxide (NO), and triggers the release of tissue factor (TF), cumulatively contributing to the formation of microclots in the pulmonary vasculature [3,4]

SB2024046), Chinese Academy of Medical Sciences & Peking Union Medical College, and written informed consents were acquired from all patients

Asparagine, especially when followed by glycine in the sequence (Asn-Gly), is a "hot spot" for deamidation