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This section will systematically elaborate on two key processes underlying this proposed systemic inflammatory cascadenamely, the overflow of testicular inflammatory mediators into the circulation and the activation and migration of immune cellsand discuss their potential implications for distant organ function ( Figure 2 )

Update on the aldehyde dehydrogenase gene (ALDH) superfamily

Consistently, overexpressing Asic1a had the opposite effect, suggesting that ASIC1a forms part of a feedback inhibition circuit that controls seizure severity (Ziemann et al., 2008)

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