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The most common side effects of OPZELURA in people treated for nonsegmental vitiligo include: acne at the application site, itching at the application site, common cold (nasopharyngitis), headache, urinary tract infection, redness at the application site, and fever

Most participants approach weight loss plateau around weeks 40-48, though clinical trial data showed participants were still losing weight at study conclusion, suggesting even longer treatment courses might yield additional benefits

A strength of this work was that these findings were then validated by shRNA knockdown of IRP2 and its negative regulatory E3 ubiquitin ligase FBXL5, which resulted in reduced and enhanced sensitivity to ferroptosis induction, respectively