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4b) and glutathione peroxidase activity (GPX4) (Fig

However, despite the advantages of lipid-based nanodrug carriers, they still face challenges related to solubility, stability, and aggregation ( Polymer-based nanodrug carriers are another widely used carrier system, typically made from synthetic or natural polymer materials such as polylactic acid (PLA), polyethylene glycol (PEG), and poly (D,L-lactic-co-glycolic acid) (PLGA) (Shi et al., 2022)

Specific to CoV, in vitro studies demonstrate that RV inhibits MERS-CoV infection by decreasing nucleocapsid protein expression resulting in reduced viral production and increased cell survival 33

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