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First, as alluded to above, restoration of wild type function to mutant p53 by APR-246 might increase sensitivity to chemotherapeutic drugs that depend on wild type p53 for induction of efficient tumor cell apoptosis
Diabetes Care 34 , 9095 (2011)

During ferroptosis, the release of iron and lipid peroxides triggers TAM reprogramming, shifting them toward an anti-tumor M1-like phenotype
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