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Lancet 2001;358:17549.ArticlePubMed 33

However, the focus is generally on how the nasal delivery devices could achieve the maximum dose deposition in the upper part of the nose cavity, thus targeting the brain

The warmth promotes relaxation and stimulates the release of endorphins, reducing stress levels

The following comparison summarizes the key considerations: For patients with intact GI absorption, oral high-dose supplementation (1,000 to 2,000 mcg daily) provides a convenient and cost-effective path to correcting deficiency