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Such endogenous rhythms, observed in organisms ranging from photosynthetic prokaryotes to higher eukaryotes, reflect the existence of an intrinsic circadian clock that temporally orchestrates physiological and behavioral processes 2 with the specific function of coordinating and adapting the internal environment with the external cues 3

During this process, which involves 10 enzymatically catalyzed steps, two molecules of ATP are expended ( investment stage) to build up a nearly symmetric intermediate, fructose-1,6-bisphosphate (Fru-1,6-BP), which is then cleaved ( splitting stage) to two three-carbon triose phosphates

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