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Hence, the hub-bottlenecks (HB) nodes are the most topologically relevant nodes and retain critical regulatory roles within the cell, being classified as bridges between biological processes and key molecular modulators (Yu et al

10.1080/01480545.2018.1454459 34 DasA

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle