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Autosomal-recessive intellectual disability with cerebellar atrophy syndrome caused by mutation of the manganese and zinc transporter gene SLC39A8

This bypasses the digestive system allowing for full absorption of the vitamin

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The high amount of formate in the culture system is a stress factor for the bacterial growth 43 , and the bacteria need to remove this intermediate product during the metabolism of oxalate to prevent formate accumulation in the culture system