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Introduction Hyperammonaemic encephalopathy (HE) is a condition characterized by dysfunction of the central nervous system due to excessively high levels of ammonia (NH 3 ) in the blood (hyperammonaemia) ( The association between VPA, a widely used AED, and HE has been has been extensively documented in numerous studies, indicating a significant correlation between the two

doi: 10.1152/ajpcell.00006.2014 60 ChenDLiXZhangLZhuMGaoL

However, after administration of 1.5 g of carnitine, TMAO levels remained elevated and did not return to baseline levels within the same timeframe

These are usually temporary and resolve with dose adjustment or switching to a different additive