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Downstream of glycolysis, ATP generation through the mitochondrial TCA and electron transport is significantly reduced, even when substrate is in abundance [64, 72]

13 Remarkably, these studies have revealed a gradual decline in gene expression associated with melanin production as individuals age, particularly in white hair follicles compared to black hair follicles

This process, using glutamate (Glu), cysteine (Cys), and glycine (Gly) as raw materials, depends on glutamate cysteine ligase (GCL) and glutathione synthetase (GS) catalysis, present only in the cytoplasmic matrix [23]

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