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IVF protocols that require high-dose progesterone may trigger symptoms, which is why coordinated care and, in some cases, progesterone desensitization are used
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It's interesting to note that it can considerably prolong the relapse time in MS patients by lowering the levels of pro-inflammatory factor IFN- and raising the levels of anti-inflammatory factors IL-35 and IL-10 when paired with methylprednisolone (283)
