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An intraventricular delivery of BMP4 for 714 days (45 or 46 week of cuprizone diet) transiently increased the proliferation predominantly of OPC and to a lower degree of astrocytes and microglia

This study adds to this body of work by providing a temporal dimension to proteomic profiling, demonstrating how maturity-dependent protein expression impacts organoid functionality

From a mechanistic perspective, the pathways are largely non-overlapping

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