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doi: 10.1002/eji.201948327 134 PathakMLalG

Even very slight injury may continue and cause joint deterioration, which can eventually lead to osteoarthritis due to the avascular cartilage's limited potential for self-repair

This action activates a surge in growth hormone release

Links exist between IL-1 and GHRH/growth hormone (GH) in promoting sleep so that IL-1 induced GH release via GHRH 56 , and hypothalamic -aminobutyric acid (GABA)ergic neurons (promoting sleep) are responsive to both GHRH and IL-1 57
