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The mechanism(s) by which duloxetine relieves pain are unclear, but blockade of neuronal sodium channels is thought to be involved (Wang 2010)

Whole body knockout of PP2Cm abrogates the dephosphorylation and increase the hyperphosphorylation of the E1 subunit of BCKDH complex in mice liver and heart (Lu et al., 2009

Animal studies have found that vitamin E inhibits stone initiation by reducing calcium oxalate crystallization, inhibiting crystal deposition in kidney tubule cells, and protecting against oxidative injury in kidney cells (Huang 2006
