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A typical cycle might involve three months of standard twice-daily application followed by one month of increased concentration or frequency, then return to maintenance levels

[6] It was noticed that liver tissue obtained from patients aged 60 to 80 years had an increased level of fibrinogen

The advantage of this type of compounds, apart from the reduction in side effects, is their efficient metabolism to non-toxic products and a high affinity for specific molecular targets, which can potentially be associated with enhanced treatment efficacy, enabling the use of a relatively low dose to produce identical biological effects [3]

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